内皮脂肪酶与冠心病的相关性研究

目的检测冠心病患者血浆内皮脂肪酶(EL)水平,探讨EL与冠心病的相关性。方法选取81例冠心病患者,并根据临床表现分为稳定性心绞痛(SAP)(n=18)、不稳定性心绞痛(UAP)(n=23)、急性心肌梗死(AMI)(n=21)及对照组(n=19)。所有患者分别进行病史采集,并检测空腹血糖(FBG)、血脂、高敏C反应蛋白(hs-CRP)、EL水平,分析EL与年龄、性别、吸烟比例、HDL-C、LDL-C、FBG、hs-CRP及冠状动脉病变程度的相关性。结果对照组血浆EL水平为(346.4±54.3)μg/L,而SAP组、UAP组、AMI组分别为:(693.2±89.7)μg/L、(780.3±99.2)μg/L(、962.5±123.3)μg/L,各组间EL水平比较差异有统计学意义(P<0.05);EL与HDL-C、LDL-C、FBG及hs-CRP明显相关(P<0.05);Gensini评分SAP组分别与UAP组、AMI组比较,差异有统计学意义(P<0.01),冠心病组EL平均水平与冠状动脉狭窄程度Gensini平均评分呈正相关(r=0.483,P<0.01)。结论冠心病患者体内EL表达明显增高,EL在冠心病的发生中可能起一定的作用。

Correlation study of endothelial lipase to coronary heart disease

Objective To investigate the correlation between plasma endothelial lipase(EL) level and coronary heart disease(CHD). Methods A total of 81 patients were enrolled and divided into four groups: stable angina pectoris group(SAP,n=18),unstable angina pectoris group(UAP,n=23),acute myocardial infarction group(AMI,n=21) and control group(n=19).Clinical history was collected and fasting blood glucose(FBG),high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C),high sensitive-C reactive protein(hs-CRP) levels were determined.Relevance of EL to age,sex,smoking proportion,HDL-C,LDL-C,FBG,hs-CRP levels and coronary lesion was analyzed. Results Plasma EL level was(346.4±54.3) μg/L in the control group,(693.2±89.7) μg/L in SAP group,(780.3±99.2) μg/L in UAP group and(962.5±123.3) μg/L in AMI group.The differences among the four groups were statistically significant(P<0.05).Significant correlation between EL level and HDL-C,LDL-C,FBG and hs-CRP levels were found(all P<0.05).Gensini scoring of SAP group was significantly different from the other three groups(all P<0.05).There was positive correlation between EL level and coronary lesion(r=0.483 P<0.01). Conclusions EL expression is increased in CHD patients.EL might play an important role in the genesis of CHD.