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7-Ethoxycoumarin O-deethylase induction by phenobarbitone and 1,2-benzanthracene in primary maintenance cultures of adult rat hepatocytes |
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| Authors: | Jeffrey R Fry Philip Wiebkin James W Bridges |
| Institution: | Institute for Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey GU2 5XH, U.K. |
| Abstract: | The microsomal monooxygenase system of adult rat hepatocytes in short-term non-proliferating culture could be induced by phenobarbitone and benzanthracene. Differences in the kinetics of induction and the additive nature of the inductions indicated that induction by the two agents occurred by different mechanisms and the use of haemoprotein-selective inhibitors demonstrated the induction of different haemoproteins by the two agents. The type of haemoprotein present in the cells altered during a four day culture period. |
| Keywords: | AHH aryl hydrocarbon hydroxylase ANF α-naphthoflavone BA benzanthracene 7-ECOD 7-HC 7-hy-droxycoumarin MMO microsomal monooxygenase PB phenobarbitone PPO diphenyloxazole the microsomal haemoprotein induced by PB To whom correspondence should be addressed |
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