肺性脑病患者血清神经元特异性烯醇化酶活性的研究

对 15例慢性肺心病合并肺性脑病患者及 10例无肺性脑病的肺心病患者 (对照组 )血清神经元特异性烯醇化酶 (NSE)活性进行测定。结果显示 :中、重型肺性脑病患者血清NSE活性较轻型肺性脑病、治疗缓解后及对照组患者明显增高 (P <0 .0 5 ) ;且血清NSE活性与动脉血氧分压呈负相关 ,与二氧化碳分压呈正相关。提示血清NSE活性可以反映慢性肺心病患者缺氧、二氧化碳潴留引起的脑损害程度

Study of plasma neuron-specific enolase activity of patients with chronic pulmonary heart disease Complicated by pulmonary encephalopathy

The plasma neuronspecific enolase (NSE) activity in the 15 patients of chronic pulmonary heart disease complicated by pulmonary encephalopathy and 10 chronic pulmonary heart disease without pulmonary encephalopathy (controls) were detected. The results showed that NSE activity in patients with moderate, severe pulmonary encaphalopathy were significantly higher than those of patients with mild pulmonary encephalopathy, stable patients and controls. The plasma NSE activity from the patients with pulmonary encephalopathy were negatively correlated with the PaO 2 and were positively correlated with PaCO 2. This study suggests that plasma NSE activity may reflect the degree of brain damage by chronic hypoxia and remain of CO 2 in the patients with chronic pulmonary heart disease. [