| 抗糖尿病新化合物MCC-555合成工艺的改进 |
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| 引用本文： | 孙良鹏,吴艳玲,郑光浩,朴虎日. 抗糖尿病新化合物MCC-555合成工艺的改进[J]. 延边医学院学报, 2006, 29(3): 172-174 |
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| 作者姓名： | 孙良鹏 吴艳玲 郑光浩 朴虎日 |
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| 作者单位： | 延边大学药学院,吉林延吉133000 |
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| 摘 要： | [目的]优化化合物MCC的合成工艺.[方法]以6-羟基-2-萘甲醛为原料,经Knoevenagel缩合反应、Williamson成醚反应及催化氢化反应合成得到目标化合物.[结果]中间体及产物的结构经IR,1HNMR和MS确证,总产率为66.5%.[结论]合成工艺反应条件温和,操作简便,反应可控性好,适合于工业生产.
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| 关 键 词： | 化学,药物 糖尿病 合成 |
| 文章编号： | 1000-1824(2006)03-0172-02 |
| 收稿时间： | 2006-06-04 |
| 修稿时间： | 2006-06-04 |
Improvement of synthesis of novel antidiabetic agent MCC-555 |
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| SUN Liang-peng,WU Yan-ling,ZHENG Guang-hao,PIAO Hu-ri. Improvement of synthesis of novel antidiabetic agent MCC-555[J]. Journal of Medical Science Yanbian University, 2006, 29(3): 172-174 |
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| Authors: | SUN Liang-peng WU Yan-ling ZHENG Guang-hao PIAO Hu-ri |
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| Affiliation: | Yanbian University College of Pharmacy, Yanji 133000, Jilin, China |
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| Abstract: | OBJECTIVE To synthesize METHODS MCC-555 was synthesized the using compound MCC-555 that possessing antidiabetic activity condensation reaction, williamson reaction and 6- hydroxy-napthalene-2-carbaldehyd through hydrogenation reaction. RESULTS The intermediates and target compound were determined by IR, 1H-NMR and MS. The total yield CONCLUSION A simple and easily controlled process for synthesis of MCC-555 was established knoevenagel structures of was 66.5 %. |
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| Keywords: | chemistry, pharmaceutical diabetes mellitus synthesis |
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