10—羟基癸烯酸对小鼠免疫功能的影响

观察蜂王浆的提取物10—羟基癸烯酸(10—HDA)对小鼠免疫功能的影响。选用雄性小鼠,ig及ip给药。结果表明,给药组小鼠的腹腔巨噬细胞对鸡红细胞的吞噬百分率和吞噬指数均较对照组为低。虽然10—HDA对小鼠外周血淋巴细胞计数无明显影响,但能抑制由PHA诱导的小鼠体内淋巴细胞转化。实验中还观察了10—HDA对小鼠肾上腺Vit C含量的影响。1次给药小鼠肾上腺的Vit C含变化不显著。给药7d的小鼠肾上腺VitC含量较对照组明显增加。该结果与ACTH给药后的效应一致。实验结果提示,10—HDA对小鼠免疫功能有一定的抑制作用,该抑制作用与其促进肾上腺皮质的功能有关。

THE EFFECTS OF 10-HDA ON IMMUNE FUNCTION OF MICE

We observed the effects of 10-hydroxy-decenoic acid ( 10-HDA ) extracted from royal jelly on the immune function of mice. It was showed that after ig or ip administration of 10-HDA, the phagocytosis of mouse peritoneal macrophages to cock red blood cells was inhibited. Although the count of lymphocytes in mouse peripheral blood was not changed after administration of 10-HDA, the in vivo lymphocyte tran- sformation of mice induced by PHA was significantly enhanced. It was also showed in our experiment that after 7d administration of 10-HDA, the content of vitamin C in adrenal glands of mice was significantly increased ( same as after ACTH administration ) . The results of our experiments indicated that 10-HDA has the inhibiting effect on immune function of mice and this effect may be related to enhancing adrenal cortex function.