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Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report |
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| Authors: | Angelica Garcia Nam‐Joon Yi Kyoung Bun Lee Jeong‐Moo Lee Young Rok Choi Suk‐Won Suh Tae You Kwang‐Woong Lee June Dong Park Hyoung Jin Kang Joon Gon Kim Eun Kyeong Kang Geun Hong Kyung‐Suk Suh |
| Institution: | 1. Department of Surgery, Seoul National University College of Medicine, , Seoul, Korea;2. Department of Pathology, Seoul National University College of Medicine, , Seoul, Korea;3. Department of Pediatrics, Seoul National University College of Medicine, , Seoul, Korea;4. Cancer Research Institute, Seoul National University College of Medicine, , Seoul, Korea;5. Department of Pediatrics, Dongguk University Ilsan Hospital, , Goyang, Korea |
| Abstract: | Dapsone is a sulfone‐type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi‐organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12‐yr‐old girl who suffered from fulminant hepatitis and multi‐organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease. |
| Keywords: | fulminant hepatitis dapsone hypersensitivity syndrome liver transplant pigmented purpuric dermatosis |