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Role of Preoperative Breast MRI in Ductal Carcinoma In Situ for Prediction of the Presence and Assessment of the Extent of Occult Invasive Component |
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| Authors: | Jacopo Nori MD Icro Meattini MD Elisabetta Giannotti MD Dalmar Abdulcadir MD Giovanna Mariscotti MD Massimo Calabrese MD Francesca Angelino MD Fabio Chiesa MD Calogero Saieva MD Ermanno Vanzi MD Cecilia Boeri MD Simonetta Bianchi MD Luis Sanchez MD Lorenzo Orzalesi MD Donato Casella MD Tommaso Susini MD Lorenzo Livi MD |
| Affiliation: | 1. Diagnostic Senology Unit, Florence University, , Florence, Italy;2. Radiation‐Oncology Unit, Florence University, , Florence, Italy;3. Istituto di Radiologia Diagnostica ed Interventistica, Turin University, , Turin, Italy;4. IRCCS San Martino‐IST, , Genoa, Italy;5. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), , Florence, Italy;6. Pathological Anatomy Division, Florence University, , Florence, Italy;7. Surgery Unit, Department of Medical and Surgical Critical Care, Florence University, , Florence, Italy;8. Department of Women and Child Health, Florence University, , Florence, Italy |
| Abstract: | Ductal carcinoma in situ (DCIS) is a common neoplasm that may be associated with focal invasive breast cancer lesions. The aim of our study was to evaluate the role of preoperative magnetic resonance imaging (MRI) in determining occult invasive presence and disease extent in patients with preoperative diagnosis of pure DCIS. We analyzed 125 patients with postoperative pure DCIS (n = 91) and DCIS plus invasive component (n = 34). Diagnostic mammography (MRX) showed a size underestimation rate of 30.4% while MRI showed an overestimation rate of 28.6%. Comparing the mean absolute error between preoperative MRI and MRX evaluations and final disease extent, MRI showed an improved accuracy of 51.2%. In our analysis preoperative breast MRI showed a better accuracy in predicting postoperative pathologic extent of disease, adding strength to the growing evidences that preoperative MRI can lead to a more appropriate management of DCIS patients. |
| Keywords: | breast cancer ductal carcinoma in situ extent disease occult invasive component preoperative MR imaging |