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Circular muscle contraction in the mice rectum plays a key role in morphine‐induced constipation |
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| Authors: | H. Ono A. Nakamura K. Matsumoto S. Horie G. Sakaguchi T. Kanemasa |
| Affiliation: | 1. Pain & Neurology, Medicinal Research Laboratories, Shionogi and Co., Ltd., , Toyonaka, Osaka, Japan;2. Laboratory of Pharmacology, Josai International University, , Togane, Chiba, Japan;3. Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, , Kyoto, Japan |
| Abstract: | |
| Keywords: | constipation morphine nitric oxide (NO) rectum μ ‐opioid receptor (MOR) |