|
|||||
|
|
Cutaneous squamous cell carcinoma in two pediatric lung transplant patients on prolonged voriconazole treatment |
|
| Authors: | Jackson Y. Wong Paul Kuzel John Mullen Dale Lien Muhammad Mahmood Carol Conrad Loretta Fiorillo |
| Affiliation: | 1. Department of Pediatrics, University of Alberta, , Edmonton, Alberta, Canada;2. Division of Dermatology, Department of Medicine, University of Alberta, , Edmonton, Alberta, Canada;3. Department of Surgery, University of Alberta, , Edmonton, Alberta, Canada;4. Department of Medicine, University of Alberta, , Edmonton, Alberta, Canada;5. Department of Laboratory Medicine and Pathology, University of Alberta, , Edmonton, Alberta, Canada;6. Pediatric Lung and Heart‐Lung Transplant Program, Stanford University, , Stanford, CA, USA;7. Department of Pediatrics, Stanford University, , Stanford, CA, USA |
| Abstract: | Oral voriconazole is commonly used for treatment and prophylaxis of invasive fungal disease post‐LTx. Development of cutaneous SCC has been described in adult LTx recipients, although it is extremely rare in children. We describe two Caucasian children who developed cutaneous SCC beyond three yr post‐LTx. Both developed severe photosensitivity, actinic keratosis and required curative surgical excision of the cutaneous SCC lesions. Neither patient developed metastatic lesions nor had allograft dysfunction as a result of the SCC or the change in medical treatments. The effect of voriconazole on the development of malignant skin lesions is discussed and a recommendation on dermatologic surveillance, preventive measures against phototoxicity and early treatment of SCC are provided. |
| Keywords: | lung transplantation squamous cell carcinoma voriconazole malignancy skin cancer organ transplantation pediatrics |