Acute lymphoblastic leukemia in a girl with Wilson's disease |
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Authors: | Sayaka Maeda Hiroshi Matsubara Eitaro Hiejima Atsushi Tanaka Masayuki Okada Itaru Kato Katsutsugu Umeda Hidefumi Hiramatsu Ken‐ichiro Watanabe Toshio Heike Souichi Adachi |
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Institution: | 1. Department of Pediatrics, Kyoto University Hospital, , Kyoto, Japan;2. Department of Pediatrics, Tenri Hospital, , Tenri, Japan;3. Faculty of Medicine, School of Human Health Sciences, Kyoto University, , Kyoto, Japan |
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Abstract: | Wilson's disease (WD) is an autosomal recessive defect in cellular copper transportation. Although acute lymphoblastic leukemia (ALL) is the most common form of childhood malignancy, only two cases of ALL associated with WD have been reported to date. One patient died of relapse and infection, and the other died of neutropenic sepsis during the treatment. We here describe the case of a 10‐year‐old girl with WD and ALL. Adverse events of chemotherapy, including liver toxicity and severe myelosuppression, necessitated adjustments in the chemotherapy doses. After completion of the treatment, the patient has remained in remission from ALL without progression of liver damage for 2 years. Severe treatment‐related toxicity should be considered in chemotherapy for patients with WD. |
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Keywords: | ATP7B d‐penicillamine glutathione‐S‐transferase liver toxicity zinc acetate |
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