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Instability of KCNE1‐D85N that Causes Long QT Syndrome: Stabilization by Verapamil
Authors:SHINJI SAKATA M.D.  YASUTAKA KURATA M.D.   Ph.D.  PEILI LI M.D.   Ph.D.  TOMOMI NOTSU M.B.  KUMI MORIKAWA Ph.D.  JUNICHIRO MIAKE M.D.   Ph.D.  KATSUMI HIGAKI Ph.D.  YASUTAKA YAMAMOTO M.D.   Ph.D.  AKIO YOSHIDA M.D.   Ph.D.  YASUAKI SHIRAYOSHI Ph.D.  KAZUHIRO YAMAMOTO M.D.   Ph.D.  MINORU HORIE M.D.   Ph.D.  HARUAKI NINOMIYA M.D.   Ph.D.  SUSUMU KANZAKI M.D.   Ph.D.  ICHIRO HISATOME M.D.   Ph.D.
Affiliation:1. Department of Pediatrics, Faculty of Medicine, Tottori University, , Yonago, Japan;2. Department of Physiology, Kanazawa Medical University, , Kahoku‐gun, Ishikawa, Japan;3. Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, , Yonago, Japan;4. Division of Cardiology, Tottori University Hospital, , Yonago, Japan;5. Gene Research Center, Tottori University, , Yonago, Japan;6. Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, , Shiga, Japan;7. Department of Biological Regulation, Faculty of Medicine, Tottori University, , Yonago, Japan
Abstract:
Keywords:long QT syndrome  KCNE1  D85N polymorphism  delayed‐rectifier K+ channel current  verapamil  amiodarone
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