Interleukin‐17 Facilitates the Immune Suppressor Capacity of High‐Grade Glioma‐Derived CD4 (+) CD25 (+) Foxp3 (+) T Cells Via Releasing Transforming Growth Factor Beta |
| |
| Authors: | H Liang L Yi X Wang C Zhou L Xu |
| |
| Institution: | Department of Neurosurgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, , Chongqing, China |
| |
| Abstract: | High‐grade glioma is a malignant tumour; the pathogenesis is to be further investigated. Interleukin (IL)‐17 is an inflammatory cytokine. Chronic inflammation is a pathological feature of cancer. This study aimed to characterize the glioma‐derived IL‐17+ regulatory T cells (Treg). In this study, single cells were isolated from surgically removed high‐grade glioma tissue and examined by flow cytometry. The immune suppressor effect of IL‐17+ Tregs on CD8+ T cells was assessed in vitro. The results showed that abundant IL‐17+ Tregs were found in high‐grade glioma tissue. The immune suppressor molecule, transforming growth factor (TGF)‐beta, was detected in the IL‐17+ Tregs. The proliferation of CD8+ T cells was suppressed by culturing with the IL‐17+ Tregs, which was partially abrogated by neutralizing antibodies of either TGF‐beta or IL‐17 and completely abrogated by neutralizing antibodies against both TGF‐beta and IL‐17. In conclusion, IL‐17+ Tregs exist in the high‐grade glioma tissue; this subset of T cells can suppress CD8+ T cell activities via releasing TGF‐beta and IL‐17. |
| |
| Keywords: | |
|
|
