风湿病中关节炎与支原体感染的关系研究

目的　应用套式聚合酶链反应 (nPCR)检测技术探讨风湿病中关节炎与支原体感染的关系。方法　对 2 6例类风湿关节炎 (RA) ,2 4例反应性关节炎 (ReA)、3例系统性红斑狼疮 (SLE)、1例干燥综合症 (SS)、1例骨关节炎 (OA)、1例未分化结缔组织病 (UCTD)、3例强直性脊柱炎 (AS)病人关节液用nPCR方法联合检测支原体 :解脲脲原体 (Uu)、人型支原体 (Mh)、发酵支原体 (Mf)、关节炎支原体 (Mar)。结果　 2 6例RA患者中 ,2例Uu阳性、1例Mh阳性、1例Mar阳性。 2 4例ReA患者中 ,2例Uu阳性、2例Mh阳性。 3例SLE患者中 ,1例Uu阳性。2例Mh阳性 ,1例SS患者Mh阳性。结论　风湿病中关节炎与支原体感染有密切关系 ,支原体感染可能是风湿病发病的一个重要因素之一。

Study on the Association between Arthritis of Rheumatic Disease and Mycoplasma Infection

Objective To explore the association between arthritis of rheumatic disease and mycoplasma infection by nested-PCR. Methods Mycoplasma, in which ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh) and mycoplasma fermentans (Mf) and mycoplasma arthritis (Mar) were studied in the synovial fluid of patients suffering from different arthritis by nested-PCR. There were about fifty-nine patients, twenty-six patients with rheumatoid arthritis (RA), twenty-four patients with reactive arthritis (ReA), three patients with systemic lupus erythmatosus (SLE), one patients with sjogran's syndrom (SS), one patient with osteoartheitis (OA), one patient with undifferentiation tissue disease (UCTD), three patients with ankylosing spondylitis (AS). Results Uu was detected in 2 of 26 RA and 2 of 24 ReA and 1 of 3 SLE patients, Mh was detected in 1 of 26 RA and 1 of 24 ReA and 2 of 3 SLE and 1 SS patients. Mar was detected in 1 of 26 RA patients. Conclusions There was association between arthritis of rheumatoid disease and mycoplasma infection. Mycoplasma may be important agent in the etiology of rheumatoid disease.