肺癌多药耐药基因表达与化疗耐药的临床研究

目的：研究P-糖蛋白在肺癌中的表达及其与肺癌化疗耐药之间的关系。方法：对33例原发性肺癌病例的癌组织病理切片进行免疫组织化学检测，了解P-糖蛋白在肺癌组织中的阳性表达率。结果：P-糖蛋白在肺腺癌、鳞癌及小细胞癌中的阳性表达率分别是62．5％、14.2％和O2在不能手术切除而进行全身化疗的12例患中，P-糖蛋白表达阴性的8例患，有6例PR或CR；而P-糖蛋白表达阳性的4例，全部无效或进展。结论:P-糖蛋白阳性表达率在肺腺癌中最高，鳞癌次之，小细胞肺癌最低；P-糖蛋白是导致肺癌耐药的主要原因。

Clinical study on multidrug- resistant gene and resistance to chemotherapy in pulmonary cancer patients

Objective To investigate the expression of p-glucoprotein in lung carcinoma and the relationship between lung carcinoma and drug resistance. Methods immunocytochemical detection of pathological sections of 33 primary pulmonary carcinoma patients' tissue was carried out for understanding the positive expression of p-glucoprotein. Results The positive rates of p-glucoprotein expressed pulmonary adenocarcinoma, squamous and small cell carcinoma were 62.5%,14.2% and 0, respectively. Negative expression of p-glucoprotein was observed in 8 out of the 12 patients not suitable for operational treatment and undergone general chemotherapy. Of the 8 patients 6 were complete or partial relieved. The treatment failed or worsen in other 4 patients positive expression of p-glucoprotein. Conclusion P-glucoprotein is the main cause resulting in pulmonary carcinoma and its expression rate is the highest in adenocarcinoma, next in squamous carcinoma and lowest in small cell carcinoma.