| ATP对脑血管在过度通气时反应性的影响 |
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| 引用本文： | 张毅 山锦. ATP对脑血管在过度通气时反应性的影响[J]. 中华麻醉学杂志, 1994, 14(4): 256-257 |
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| 作者姓名： | 张毅 山锦 |
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| 作者单位： | 昆明医学院附属一院麻醉科!邮政编码650032(张毅，莫治强)，云南省邮电医院外科(山锦，李畅民) |
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| 摘 要： | 使用经颅多普勒（ＴＣＤ）无创性观察 ＡＴＰ对 １５例患者大脑中动脉血流速度和对过度通气反应的影响。以１％普鲁卡因（每分钟１ｍｌ／ｋｇ）和吸入１％安氟醚及４０％Ｎ２Ｏ维持麻醉。使用ＴＣＤ监测静滴ＡＴＰ前后左大脑中动脉平均血流速度，并计算脑血管对过度通气的反应性。脑血管反应性以ＰＥＴＣＯ２每变化１ｋＰａ所致脑血流速度变化的百分率表示。静滴１％ＡＴＰ使ＭＡＰ下降３４％期间，平均血流速度由６１．５降至５３．１ｃｍ／ｓ（Ｐ＜０．０１），而脑血管对过度通气的反应性无明显变化。总之，ＡＴＰ控制性降压期间可使大脑中动脉血流速度减慢，但仍可保持脑血管对过度通气反应性的存在。
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| 关 键 词： | ATP 过度通气 脑血管反应性 |
Etfects of ATP on cerebral blood flow velocity and vascular responses during hyperventilation. |
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| Zhang Yi.Mo Zhi-qiang,Shan Jin,et al. Etfects of ATP on cerebral blood flow velocity and vascular responses during hyperventilation.[J]. Chinese Journal of Anesthesilolgy, 1994, 14(4): 256-257 |
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| Authors: | Zhang Yi.Mo Zhi-qiang Shan Jin et al |
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| Affiliation: | Zhang Yi.Mo Zhi-qiang,Shan Jin,et al Department of Anesthesiology,the First Affiliated Hospital,Kunming Medical College,Kunming 650032 |
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| Abstract: | The effects of ATP on cerebral blood flow velocity and vascular responses to hyperventilation using TCD in the middle cerebral artery were studied in 15 patients. Anesthesia was maintained by infusion of 1% procaine (1ml.kg-1/min) and inhalation of 1% enflurane-40%N2O-O2. Mean blood flow velocity in left middle cerebral artery was measured and cerebral vascular reactivity to hyperventilytion was assessed before and during the administration of ATP.The cerebral reactivity was expressed as the percentage change in mean blood flow velocity per unit change in PETCO2. During the administration of 1%ATP,a 34% reduction in MAP with mean blood flow velocity decreased significantly from 61.5 to 53.1cm/s (P
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| Keywords: | ATP Hyperventilation Cerebrovascular Reactivity |
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