连续硬膜外输注利多卡因的临床及药代动力学研究

通过对间断追加药物组与连续输注组的临床及药代动力学的观察比较，了解持续硬膜外输注利多卡因在临床麻醉中应用的可行性。结果表明：采用持续硬膜外输注法同样可维持良好的镇痛与肌松作用，且无明显不良反应。其血浆利多卡因浓度与间断给药组无显著差异。但间断给药组药－时曲线波动明显，而输注组药－时曲线平稳。药代动力学参数除消除半衰期和表观分布容积有显著差异外，余参数无临床生理意义的差异。本研究证实，持续输注法是临床硬膜外阻滞的可行且安全的方法之一。

Application and pharmacokinetics of Ontinuous epidural lidocaine infusion

ASA patients, 25 ~ 66 years old, were randomly devided into 2 groups. GI were initially receieved 15ml of 2% lidocaine and then followed by 8ml epidurally at 1h intervals; G2 initially receieved 15ml 2% lidocaine and followed by a constantly epidural infusion of 8ml/h 2% lidocaine. The result of clinical observation showed that adequate muscle relaxation and analgisia can be achieved by continuously epidural without significant adverse reactions. Pharmacokinetics analysis suggested that the blood concentration of lidocaine has no significant differences between GI and G2, but the G2 has a advan tage of appearing a much smooth concentration-time curve, compared with the G1,especially,the T1/2 of elimination in G2 was much longer than that in G1 (P 0.05). It'S concluded that continuous epidural infusion is an effective,safe and feasible method for epidural anesthesia.