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Frontal Behavioural Inventory in the differential diagnosis of dementia |
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| Authors: | Milan G Lamenza F Iavarone A Galeone F Lorè E de Falco C Sorrentino P Postiglione A |
| Institution: | Department of Clinical and Experimental Medicine, University "Federico II", Naples, Italy;;Centro Geriatrico Sovradistrettuale Frullone, ASL Napoli 1, Naples, Italy;;Geriatric Unit, General Hospital, Rossano (Cosenza), Italy;;Neurological and Stroke Unit, CTO Hospital, Naples, Italy;;Department of Geriatrics, ASL Napoli 1, Naples, Italy;;Istituto Diagnosi e Cura, Hermitage Capodimonte, Naples, Italy |
| Abstract: | Objective – To evaluate diagnostic properties of the Frontal Behavioural Inventory (FBI) in patients suffering from different forms of dementia. Methods – The FBI was administered with other psychometric tests investigating cognitive performances and behavioral scales to the caregivers of 35 patients with the frontal variant of frontotemporal dementia (fv-FTD), 22 patients with Alzheimer's disease (AD) and 15 with vascular dementia (VaD). All patients were comparable for degree of dementia severity and level of executive impairment. Results – The FBI showed high concurrent validity, internal consistency and good inter-rater and test–retest reliability. The discriminant validity was also very high. A new FBI cut-off score of 23 gave 97% sensitivity and 95% specificity in distinguishing fv-FTD from non-FTD patients. Conversely, the Neuropsychiatic Inventory (NPI) score was unable to differentiate fv-FTD from AD. Conclusions – The FBI is a neurobehavioral tool suitable to distinguish fv-FTD from other forms of dementia also when data from cognitive testing or other behavioral scales fail to support the differential diagnosis. |
| Keywords: | frontotemporal dementia Alzheimer's disease vascular dementia behavior |
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