妊娠期肝内胆汁淤积症与胎儿预后的研究

目的:探讨妊娠合并肝内胆汁淤积症(ICP)孕妇、新生儿血清胆汁酸(CA)含量与胎儿宫内窘迫的关系;ICP与新生儿黄疸的关系。方法:选择48例ICP患者为观察组,50例正常孕妇为对照组,分别测定孕妇血清及新生儿脐静脉血清胆汁酸水平及新生儿血清胆红素水平。结果:ICP孕妇血清及新生儿脐静脉血清CA水平均较对照组明显增高,且胎儿宫内窘迫发生率亦增高;观察组新生儿血清胆红素水平明显增高,且72h内黄疸发生率增高。结论:建议测定CA水平作为预测ICP胎儿预后的一项指标;母体发生ICP可使新生儿黄疸发生率增高。

Study on intrahepatic cholestasis of pregnancy and fetal prognosis

Objective:To explore the relationship between intrahepatic cholestasis of pregnancy (ICP), serum cholic acid (CA) content in mother and infants and fetal distress and neonates' icterus.Methods:Serum CA levels of pregnant women and neonates' umbilical vein and serum bilirubin in neonates of 48 patients with ICP and 50 normal controls were determined.Results:Serum CA levels were significantly higher than those in controls, the incidence of fetal distress also increased; neonates' serum bilirubin in ICP group significantly increased and the incidence of icterus within 72 h enhanced.Conclusion:Detection of CA levels should be a predictor of prognosis of neonates with ICP, the mothers with ICP could increase incidence of neonates' icterus.