他达拉非用于前列腺术后阴茎康复的研究进展

前列腺癌根治性切除术(RP)是治疗绝大多数临床局限性前列腺癌的标准术式,保留神经的NSRRP术式的广泛采用使得RP的疗效得到了显著的提升,但是对RP术后勃起功能的保护仍是泌尿外科的难题。RP术后及早开始阴茎康复可显著改善RP术后勃起功能障碍(ED)对患者的术后生活质量。作为唯一的长效选择性磷酸二酯酶-5抑制剂(PDE5Is),他达拉非在RP术后阴茎康复中的显著疗效在临床试验和基础研究中均得到了证实。本文旨在回顾目前RP术后ED的相关进展,及他达拉非在RP术后阴茎康复中的有效性和安全性证据。

Tadalafil rehabilitation therapy for erectile dysfunction following prostatectomy

Radical prostatectomy(RP)is preferred for many patients with clinically localized prostate cancer.Despite the introduction of the nerve sparing technique and progressive modifications on RP,postoperative preservation of penile erectile function remains a challenge to urologists.Earlier initiation of penile rehabilitation can significantly improve the patient's quality of life affected by erectile dysfunction(ED) following RP.Tadalafil,a long-acting PDE5 inhibitor with a unique clinical profile,has proved effective in penile rehabilitation in the treatment of RP-associated ED in both clinical trails and animal models.This article reviews current strategies for the management of ED after RP and evaluates the efficacy and safety of tadalafil in post-RP penile rehabilitation.