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| 左旋卡尼汀对异丙肾上腺素致心肌损害的影响 | |
| 引用本文： | 钱伟,殷仁富,任建平,顾书华. 左旋卡尼汀对异丙肾上腺素致心肌损害的影响[J]. 心脏杂志, 2005, 17(1): 13-15. DOI: 10.13191/j.chj.2005.01.16.qianw.005 |
| 作者姓名： | 钱伟 殷仁富 任建平 顾书华 |
| 作者单位： | 1. 第二军医大学长征医院心内科,上海,200003 2. 军事医学科学院二所,北京,100850 3. 常州三维工业技术研究所,江苏,常州,213022 |
| 摘 要： | 目的:观察左旋卡尼汀对异丙肾上腺素致心肌损害的保护作用并探讨其机制。方法:采用大鼠皮下注射异丙肾上腺素造成心肌损害模型。心肌切片,HE染色,光镜下观察心肌损害程度;分离心肌线粒体,测定膜脂流动性（LFU）。结果:注射左旋卡尼汀可减轻心肌损害程度;改善线粒体的损伤,改善LFU。结论:左旋卡尼汀能减轻异丙肾对心肌的损害,对线粒体膜脂流动性损伤具有明显的保护作用。 |
| 关 键 词： | 左旋卡尼汀 异丙肾上腺素 线粒体 膜脂流动性 |
| 文章编号： | 1009-7236(2005)01-0013-03 |
| 修稿时间： | 2004-04-19 |
Protective effect of L-carnitine on myocardial damage induced by isoproterenol |
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| QIAN Wei,YIN Ren-Fu,REN Jian-ping,GU Shu-hua. Protective effect of L-carnitine on myocardial damage induced by isoproterenol[J]. Chinese Heart Journal, 2005, 17(1): 13-15. DOI: 10.13191/j.chj.2005.01.16.qianw.005 | |
| Authors: | QIAN Wei YIN Ren-Fu REN Jian-ping GU Shu-hua |
| Affiliation: | QIAN Wei 1,Yin Ren-fu 1,REN Jian-ping 2,GU Shu-hua 3 |
| Abstract: | AMI: To investigate the protective effect of L-carnitine on myocardial damage induced by isoproterenol and its mechanism. METHODS: Rat myocardial ischemia was induced by isoprenaline(ISO) 5 mg/kg injected subcutaneously. Sections of heart were stained with hematoxylin eosin and the degree of myocardial damage was evaluated under the microscope. Rat myocardial mitochondria were isolated, and membrane lipid fluidity (LFU) was determined. RESULTS: The degree of myocardial damage was significantly reduced in the groups treated and pretreated with L-carnitine. Injury of myocardial mitochondra was attenuated in the L-carnitine group. CONCLUSION: L-carnitine may protect the myocardium from damage by isoproterenol and may also have protective effect on LFU of mitochondria damaged by ISO. |
| Keywords: | L-carnitine isoproterenol mitochondria membrane lipid fluidity (LFU) |
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