| 针刀松解法对第3腰椎横突综合征大鼠下丘脑前阿黑皮素mRNA、前脑啡肽原mRNA表达的影响 |
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| 作者姓名： | Guo CQ Cao RJ Sun HM Mojtabavi SJ Ma HF Wu HX Xu H Li XH Liu NG Zhang Y Yue LF Qiao JL Chen ZL |
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| 作者单位： | 北京中医药大学针灸推拿学院;北京中医药大学基础医学院;解放军海军总医院康复理疗科;北京中医药大学管理学院; |
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| 基金项目： | 国家重点基础研究发展计划"973"计划,国家中医药管理局《针灸特色疗法评价》重点研究室资助,教育部《高等学校本科教学质量与教学改革工程》高等学校专业建设点项目北京市教育委员会共建项目 |
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| 摘 要： | 目的:探讨针刀松解法治疗第3腰椎横突综合征的部分中枢镇痛机制。方法:SD雄性大鼠24只,随机分为正常组、模型组、针刀组及电针组。采用左侧第3腰椎横突尖部埋置明胶海绵法建立第3腰椎横突综合征模型,针刀组和电针组分别给予针刀松解和电针左侧"肾俞""腰阳关"治疗。应用原位杂交方法检测大鼠下丘脑前阿黑皮素(POMC)mRNA、前脑啡肽原(PPE)mRNA阳性细胞的表达。结果:造模后大鼠下丘脑POMC mRNA、PPE mRNA的阳性细胞表达较正常组增多(P0.01),针刀组和电针组大鼠下丘脑POMC mRNA、PPE mRNA阳性细胞表达较模型组进一步增多(P0.01)。结论:针刀松解法与电针可能通过促进下丘脑POMC mRNA、PPE mRNA的表达,参与其镇痛过程。
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| 关 键 词： | 第3腰椎横突综合征 针刀松解法 电针 下丘脑 前阿黑皮素 前脑啡肽原 |
Effect of acupotomy lysis on hypothalamic POMC mRNA and PPE mRNA expression in rats with 3rd lumbar vertebrae transverse process syndrome |
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| Guo CQ,Cao RJ,Sun HM,Mojtabavi SJ,Ma HF,Wu HX,Xu H,Li XH,Liu NG,Zhang Y,Yue LF,Qiao JL,Chen ZL.Effect of acupotomy lysis on hypothalamic POMC mRNA and PPE mRNA expression in rats with 3rd lumbar vertebrae transverse process syndrome[J].Acupuncture Research,2010,35(5):354-8, 393. |
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| Authors: | Guo Chang-Qing Cao Rong-Juan Sun Hong-Mei Mojtabavi Seyed Javad Ma Hui-Fang Wu Hai-Xia Xu Hong Li Xiao-Hong Liu Nai-Gang Zhang Yi Yue Li-Feng Qiao Jin-Lin Chen Zhan-Lu |
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| Institution: | GUO Chang-qing,CAO Rong-juan,SUN Hong-mei1,Seyed Javad Mojtabavi,MA Hui-fang,WU Hai-xia1,XU Hong1,LI Xiao-hong,LIU Nai-gang,ZHANG Yi,YUE Li-feng1,QIAO Jin-lin2,CHEN Zhan-lu3(College of Acu-moxibustion and Massage,Beijing University of Chinese Medicine,Beijing 100029,China,1College of Preclinical Medicine,2Department of Physiotherapy,Naval General Hospital of Chinese People's Liberation Army,Beijing 100037,3 College of Management,Beijing University of Chi... |
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| Abstract: | Objective To observe the effect of acupotomy lysis(AL) on hypothalamic proopiomelanocortin(POMC) mRNA and preproenkephalin(PPE) mRNA expression in rats with the third lumbar vertebrae transverse process syndrome(TLVTPS) so as to study its underlying mechanism in relieving symptoms of lumbar muscle strain.Methods Twenty-four SD rats were randomly divided into normal control group,model group,AL group and electroacupunture(EA) group.The TLVTPS model was established by inserting a piece of gelatin sponge into ... |
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| Keywords: | Third lumbar vertebrae transverse process syndrome Acupotomy lysis Electroacupuncture Hypotha-lamus POMC mRNA PPE mRNA |
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