| 桂皮醛在大鼠肠中的体外代谢转化研究 |
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| 引用本文： | 何平均,李凯鹏,杨洁,杨丽娟,张玉杰.桂皮醛在大鼠肠中的体外代谢转化研究[J].中草药,2010,41(12):2014-2018. |
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| 作者姓名： | 何平均 李凯鹏 杨洁 杨丽娟 张玉杰 |
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| 作者单位： | 北京中医药大学中药学院, 北京 100102;中日友好医院药剂科, 北京 100029;北京中医药大学中药学院, 北京 100102;北京中医药大学中药学院, 北京 100102;北京中医药大学中药学院, 北京 100102 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的 考察桂皮醛在大鼠离体小肠中的代谢转化特性及黄连对其代谢的影响.方法 RP-HPLC法测定桂皮醛及其代谢产物肉桂酸;考察不同浓度桂皮醛在大鼠离体小肠提取液、小肠组织匀浆液中的代谢动力学及黄连对其代谢的影响.结果 桂皮醛在各种大鼠离体小肠液中均可被迅速代谢,主要代谢产物为肉桂酸;小肠各提取液对桂皮醛的代谢速率存在差异;桂皮醛浓度越低,代谢速率越快;黄连对桂皮醛的大鼠小肠代谢存在明显抑制作用.结论 桂皮醛在大鼠小肠中可迅速被代谢,主要代谢产物为肉桂酸;黄连对桂皮醛代谢具有抑制作用.
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| 关 键 词： | 桂皮醛 代谢 黄连 肉桂酸 |
| 收稿时间： | 2010/4/15 0:00:00 |
In vitro metabolic transformation characteristics of cinnamaldehyde in rat intestine |
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| HE Ping-jun,LI Kai-peng,YANG Jie,YANG Li-juan and ZHANG Yu-jie.In vitro metabolic transformation characteristics of cinnamaldehyde in rat intestine[J].Chinese Traditional and Herbal Drugs,2010,41(12):2014-2018. |
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| Authors: | HE Ping-jun LI Kai-peng YANG Jie YANG Li-juan and ZHANG Yu-jie |
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| Institution: | School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China |
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| Abstract: | Objective To research the in vitro biotransformation characteristics of cinnamaldehyde in rat intestine and the influence of Coptis chinensis on its metabolism.Methods RP-HPLC Method was applied for analyzing the content of cinnamaldehyde as well as its metabolite cinnamic acid.The stability of cinnamaldehyde in extracts of rat small intestinal mucosa side,serosal side,and homogenate was investi-gated,respectively.Also the impact of C.chinensis on this process was estimated.Results The results showed that cinnamaldehyde in rat intestine was unstable and could rapidly be transformed into cinnamic acid.C.chinensis had inhibitation on cinnamaldehyde metabolism.Conclusion Cinnamaldehyde could be metabolized in rat different intestinal extracts immediately and the main metabolite is cinnamic acid.C.chinensis shows inhibiting effect on the cinnamaldehyde metabolism. |
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| Keywords: | cinnamaldehyde metabolism Coptis chinensis Franch cinnamic acid |
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