| 中国被毛孢发酵物对NOD小鼠1型糖尿病的预防作用 |
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| 引用本文： | 寿旗扬,傅惠英,陈方明,周卫民,张才乔,陈民利.中国被毛孢发酵物对NOD小鼠1型糖尿病的预防作用[J].中草药,2010,41(8):1311-1315. |
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| 作者姓名： | 寿旗扬 傅惠英 陈方明 周卫民 张才乔 陈民利 |
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| 作者单位： | 浙江大学动物科学学院，浙江 杭州 310029；浙江中医药大学 动物实验研究中心，浙江 杭州 310053;浙江大学医学院，浙江 杭州 310058;浙江中医药大学 动物实验研究中心，浙江 杭州 310053;浙江大学动物科学学院，浙江 杭州 310029;浙江中医药大学 动物实验研究中心，浙江 杭州 310053 |
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| 基金项目： | 浙江省科技计划项目，浙江省卫生高层次创新人才培养工程项目 |
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| 摘 要： | 目的观察中国被毛孢发酵物对自发性1型糖尿病NOD小鼠的预防作用。方法利用NOD小鼠1型自发性糖尿病模型,连续10周ig给予1 g/kg中国被毛孢发酵物后,观察NOD小鼠的体质量、血糖、发病率、谷氨酸脱羧酶(GAD)抗体水平、胰岛病变和胰腺纤维化的变化。结果 NOD小鼠给予1 g/kg中国被毛孢发酵物后,第6~10周时血糖和发病率明显降低(P0.05、0.01),小鼠血清中GAD抗体明显降低(P0.01),小鼠胰岛病变和胰腺纤维化评分值显著降低(P0.05、0.01),胰腺结构较为清晰,胰岛有少量炎症细胞浸润,胰岛β细胞未见异常。结论中国被毛孢发酵物有较好的预防NOD小鼠1型糖尿病发生的作用
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| 关 键 词： | 中国被毛孢发酵物 NOD小鼠 1型糖尿病 |
| 收稿时间： | 2009/11/11 0:00:00 |
Prevention of strain fermentation in Hirsutella sinensis on type diabetes of nonobese diabetic mice |
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| SHOU Qi-yang,FU Hui-ying,CHEN Fang-ming,ZHOU Wei-min,ZHANG Cai-qiao and CHEN Min-li.Prevention of strain fermentation in Hirsutella sinensis on type diabetes of nonobese diabetic mice[J].Chinese Traditional and Herbal Drugs,2010,41(8):1311-1315. |
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| Authors: | SHOU Qi-yang FU Hui-ying CHEN Fang-ming ZHOU Wei-min ZHANG Cai-qiao and CHEN Min-li |
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| Institution: | College of Animal Sciences, Zhejiang University, Hangzhou 310029, China;The Research Center of Laboratory Animal Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;School of Medicine, Zhejiang University, Hangzhou 310058, China;The Research Center of Laboratory Animal Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;The Research Center of Laboratory Animal Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;College of Animal Sciences, Zhejiang University, Hangzhou 310029, China;The Research Center of Laboratory Animal Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China |
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| Abstract: | observe the prevention of Train ferment ation in Hir sutell asinensison sponta neoustype diabetes of non bese diabet ic ( NOD) mice. Methods the NOD mice with spontaneo ustype diabetes were adminis Trated by 1000 mg/kg strainf ermentation in H. sinensis for 10 weeks. the index including body weight. |
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| Keywords: | strain fermentation in Hirsutella sinensis X J Liu Y L Guo non-obese diabetic (NOD) mice type 1 diabetes |
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