妊娠晚期检测血清总胆汁酸的临床意义

目的探讨妊娠晚期检测总胆汁酸的临床意义。方法将400例妊娠晚期孕妇按总胆汁酸值的高低分为观察组(总胆汁酸值>20μmol/L,n=125)和对照组(总胆汁酸值≤20μmol/L,n=275),比较两组孕妇的妊娠结局。结果观察组胎儿窘迫及早产儿的发生率高于对照组,两组比较差异有统计学意义(P<0.01),两组宫内发育迟缓、新生儿中度窒息及产后出血的发生率比较差异无统计学意义(P>0.05)。结论血清总胆汁酸增高是妊娠期肝内胆汁淤积症早期诊断的敏感指标,加强对血清总胆汁酸的检测,有助于妊娠期肝内胆汁淤积症的早期诊断。从而为早期选择合适的分娩方式以及预防胎儿窘迫和早产的发生提供依据。

Clinic significance of testing serum total bile acid(TBA)for late pregnancy

Objective To investigate the clinical significance of testing total bile acid(TBA)for late pregnancy.Methods Four hundred cases of late pregnancy were divided into two groups with observation group and control group,200 cases respectively.Late pregnancy women with higher total bile acid/TBA(TBA>20μmol/L,n=125)were divided into observation group,while lower TBA(TBA≤20μmol/L,n=275)divided into control group,then to compare the pregnancy outcome of two groups.Results The incidence rate of fetal distress and premature infant of observation group was higher than control group,there were significant difference between two groups(P<0.01).And for the incidence rate of intrauterine growth retardation(IUGR),severe asphyxia neonatorum and postpartum hemorrhage,there were no significant difference between two groups.(P>0.05).Conclusion The increase of serum total bile acid(TBA)is a sensitive indicator for early diagnosis of intrahepatic cholestasis in pregnancy period.It’s useful and helpful for early diagnosis of intrahepatic cholestasis in pregnancy period to strengthen the serum total bile acid(TBA)testing.Thus can provide scientific basis for choosing a suitable childbirth way in early pregnancy,also for preventing fetal distress and premature infant.