两种阿德福韦酯制剂治疗e抗原阳性慢性乙型肝炎的疗效比较

目的对比两种不同阿德福韦酯制剂治疗e抗原阳性慢性乙型肝炎的疗效。方法将本院收治的86例e抗原阳性慢性乙型肝炎患者随机均分为治疗1组与治疗2组。分别给予两种不同阿德福韦酯制剂治疗，治疗1组给予葛兰素史克（天津）有限公司出品的阿德福韦酯片，商品名为贺维力，治疗2组给予福建广生堂药业有限公司出品的阿德福韦酯片，商品名为阿甘定，两药用法及用量均相同，于治疗6个月及治疗24个月时对两组患者的ALT复常率、HBV—DNA阴转率及HBeAg／抗HBe血清转换率进行对比，同时比较不良反应发生率及治疗用药费用情况。结果两组治疗6个月与24个月时的疗效及不良反应发生率差异均无统计学意义（P〉0．05）；治疗2组的24个月用药费用显著低于治疗1组（P〈0．01）。结论两种阿德福韦酯制剂疗效相当，不良反应发生率无明显差异，但治疗2组使用的更加经济实用。

The efficacy comparison of two adefovir dipivoxil preparations for treatment of e antigen positive chronic hepatitis B

Objective To compare the efficacy of two adefovir dipivoxil preparations for treatment of e antigen positive chronic hepatitis B.Methods Eighty-six cases of patients with e antigen positive chronic hepatitis B were randomly and averagely divided into treatment group 1 and treatment group 2,who were given two different formulations of adefovir dipivoxil therapy,treatment group 1 were given adefovir dipivoxil tablets produced by GlaxoSmithKline Tianjin Co.,Ltd.trade name was Geoffrey force,treatment group 2 were given adefovir dipivoxil tablets produced by Fujian the Guangsheng Tang Pharmaceutical Co.,Ltd.trade name was Agam,the two had the same method and amount.ALT normalization and HBV-DNA negative rate and HBeAg /anti-HBe seroconversion rates of two groups patients when 6 months and 24 months after treatment were compared,at the same time,the incidence of adverse reactions and treatment of drug costs were compared.Results The efficacy and the incidence of adverse reactions 6 months and 24 months after treatment of two groups had no significant difference(P > 0.05);24 monthly drug costs of treatment group 2 were significantly lower than that of the treatment group 1(P < 0.01).Conclusion The efficacy of two adefovir dipivoxil preparations is equivalent,the incidence of adverse reactions has no significant difference,but treatment group 2 using agam is more economical and practical.