| 丹参酮ⅡA防治骨性关节炎的研究进展 |
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| 引用本文： | 夏晓晓,黄耀凯,李中琼. 丹参酮ⅡA防治骨性关节炎的研究进展[J]. 现代药物与临床, 2024, 39(5): 1365-1376 |
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| 作者姓名： | 夏晓晓 黄耀凯 李中琼 |
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| 作者单位： | 重庆市大足区人民医院 骨科, 重庆 402360 |
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| 基金项目： | 重庆市大足区科技发展项目（DZKJ2023JSYJ-KWXM1042） |
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| 摘 要： | 骨性关节炎是以软骨细胞去分化、软骨退化和软骨缺损为特征的致残性疾病，目前尚缺乏有效的药物，临床治疗以延缓病情为主。丹参酮ⅡA是丹参中脂溶性成分，具有多种药理作用，可降低炎症反应、保护软骨组织以防治骨性关节炎。综述了丹参酮ⅡA防治骨性关节炎的研究进展，总结其作用机制，为丹参酮ⅡA临床治疗骨性关节炎提供参考。
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| 关 键 词： | 丹参酮ⅡA 骨性关节炎 炎症反应 软骨组织 作用机制 |
| 收稿时间： | 2024-02-26 |
Research progress of tanshinone ⅡA in prevention and treatment of osteoarthritis |
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| XIA Xiaoxiao,HUANG Yaokai,LI Zhongqiong. Research progress of tanshinone ⅡA in prevention and treatment of osteoarthritis[J]. Drugs & Clinic, 2024, 39(5): 1365-1376 |
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| Authors: | XIA Xiaoxiao HUANG Yaokai LI Zhongqiong |
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| Affiliation: | Department of Orthopaedics, The People''s Hospital of Dazu, Chongqing, Chongqing 402360, China |
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| Abstract: | Osteoarthritis is a disabling disease characterized by dedifferentiation of chondrocytes, cartilage degeneration, and cartilage defects. At present, there is a lack of effective drugs, and clinical treatment mainly focuses on alleviating symptoms. Tanshinone ⅡA is a lipophilic component from Salviae Miltiorrhizae Radix et Rhizoma, which has multiple pharmacological effects. Tanshinone ⅡA can reduce inflammation and protect cartilage tissue to prevent and treat osteoarthritis. This article summarizes the research progress of tanshinone ⅡA in prevention and treatment of osteoarthritis, summarizes its mechanism, and provides reference for the clinical treatment of osteoarthritis with tanshinone ⅡA. |
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| Keywords: | tanshinone ⅡA osteoarthritis inflammation cartilage tissue mechanism |
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