Treatment of benign breast disease with vitamin A |
| |
Authors: | P R Band M Deschamps M Falardeau J Ladouceur J Cote |
| |
Affiliation: | 1. Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada;2. Faculty of Nursing, University of Montreal, Montreal, Quebec, Canada |
| |
Abstract: | Twelve patients with benign breast disease (BBD) were treated with 150,000 IU of vitamin A daily taken orally. All patients were symptomatic and had measurable or evaluable breast masses. At 3 months of treatment, complete or partial responses were observed in five patients, and marked pain reduction in nine was observed. Side effects were generally mild in nature, consisting mostly of skin and mucosal changes, and were rapidly reversible upon discontinuation of the drug. Treatment was interrupted or discontinued in only two patients, and the dosage of vitamin A was reduced in one on account of toxicity. No hepatotoxicity was observed. Investigation of the chemopreventive role of either vitamin A or retinoids in patients with BBD who are at high risk of developing breast cancer is suggested. |
| |
Keywords: | To whom requests for reprints should be addressed: Cancer Control Agency of British Columbia 600 West 10th Avenue Vancouver B.C. V5Z 4E6 Canada. |
本文献已被 ScienceDirect 等数据库收录! |
|