| 中药有效成分防治阿尔茨海默病的药理研究进展 |
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| 引用本文： | 吴蕾,程淑意,王奇,陈云波. 中药有效成分防治阿尔茨海默病的药理研究进展[J]. 中国中药杂志, 2004, 29(5): 387-389 |
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| 作者姓名： | 吴蕾 程淑意 王奇 陈云波 |
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| 作者单位： | 广州中医药大学,临床科研设计、衡量评价中心,广东,广州,510405 |
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| 摘 要： | 从中医药防治阿尔茨海默病 (AD)的药理研究出发 ,结合目前有关AD发病机制的神经递质代谢障碍、细胞凋亡、炎症反应等假说 ,查阅文献并行分析总结 ,发现中药有效成分如人参皂苷、蛇床子素、红景天素、(- )黄皮酰胺等防治AD的作用机制涉及各种途径 ,其中人参皂苷可对AD的多个病理环节起效 ,为筛选AD有效药物提供了一定的依据。
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| 关 键 词： | 阿尔茨海默病 中药有效成分 药理作用 |
| 文章编号： | 1001-5302(2004)05-0387-03 |
| 收稿时间： | 2003-04-16 |
Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer''s disease |
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| WU Lei;CHENG Shu-yi;WANG Qi;CHEN Yun-bo. Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer''s disease[J]. China Journal of Chinese Materia Medica, 2004, 29(5): 387-389 |
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| Authors: | WU Lei CHENG Shu-yi WANG Qi CHEN Yun-bo |
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| Affiliation: | DME Center, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. leiwu0972@sina.com |
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| Abstract: | Based on the pharmacological research of Chinese herbs on AD and some famous hypothesis on AD, such as disfunction of nervous transmitter metabolism, apoptosis, inflammation etc, we consulted and analyzed relevant papers. We found the effective mechanism of Ginsenoside, Osthol, Rhodosin, and (-)Clausenamide were related to many pathological channels of AD, and Ginsenoside had effect on many pathological channels. The results have provided some clues for selecting effective herbs on AD. |
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| Keywords: | Alzheimer's disease active components of Chinese herbs pharmacological effects |
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