大豆异黄酮对肥胖大鼠血脂及瘦素水平的影响

目的：通过大豆异黄酮（SIF）对肥胖大鼠的干预，观察大鼠体重、血脂及血清瘦素水平的变化，探讨SIF对肥胖大鼠的减肥作用及机制。方法：用高脂饲料造成雄性大鼠肥胖模型，然后按体重将其随机分为4组，各组均继续给予高脂饲料。其中一组为肥胖对照组，灌胃生理盐水，另外三组灌胃SIF，剂量分别为50mg／kg BW、150mg／kg BW及450mg／kg BW。第4周末股动脉取血，用酶免法检测血浆中瘦素，酶法检测血脂。结果：与肥胖对照组相比，450mg／kg BW剂量组大鼠血清瘦素水平明显升高，大鼠体重、血清TG、TC水平降低（P〈0．05或P〈0．01）；150mg／kg BW剂量组大鼠的体重及血清TC水平降低（P〈0．05）。结论：SIF对肥胖大鼠有减肥作用，机制可能与SIF调节瘦素表达和分泌有关。

THE EFFECT OF SOY ISOFLAVONES ON THE LEVEL OF BLOOD LIPID AND LEPTIN OF THE OBESE RATS

Objective:To study the effects of soy isoflavones(SIF)on body weight,blood lipids level,serum leptin level of obese rats,and to discuss the mechanism of SIF effect.Methods:Male obese rats which induced by high fat diet were randomly divided into four groups.All rats were given high fat diet.One control group were gavaged with normal saline and three SIF groups were gavaged with water solutions of SIF at doses of 50 mg/kg.BW,150 mg/kg.BW,and 450 mg/kg.BW,respectively.After four weeks,body weight,fasting lipid,leptin in serum were measured.Results:Body weight of 150 mg/kg.BW and 450 mg/kg.BW groups were significantly lower than that in the control group.Compared with control group,450 mg/kg.BW group showed a significant decrease in serum triglyceride(TG),total cholesterol(TC),but serum leptin increased significantly.Conclusion:SIF may have an benificial effect on obesity related to the mechanism of regulating the secretion of leptin.