Pseudorandom testing technique for the characterization of local hemodynamic control |
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Authors: | H. Jay Rubenstein Thomas Kenner Koichi Ono |
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Affiliation: | (1) Division of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA;(2) Present address: Physiologisches Institut der Deutschen Sporthochschule, Carl-Diem-Weg, 5 Köln 41, Federal Republic of Germany;(3) Present address: Physiologisches Institut der Universität Graz, Mozartgasse 14, A-8010 Graz, Austria |
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Abstract: | Summary In order to investigate the low frequency properties of renal and femoral hemodynamic variables, pseudorandom testing techniques were used. The arterial flow of each bed, in separate experiments, was modulated by a low amplitude signal based on a pseudorandom binary sequence (PRBS) generated by digital computer.The cross-correlation functions between input flow and arterial pressure, venous pressure, and venous flow exhibit damped oscillations in all cases. These responses are parameterized in terms of a damping ratio () and an undamped natural frequency n for a second order model. The parameters of the model are dependent upon the state of the bed as defined by mean arterial and venous pressures, mean flow through the bed, resistance, and oxygen consumption.The results of this study offer further insight into the dynamic low frequency autoregulation phenomenon for the renal and femoral beds of the dog.Supported by NIH Grant HE 11747. |
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Keywords: | Pseudorandom Binary Sequence Low Frequency Hemodynamics Renal Vascular Impulse Responses Femoral Vascular Impulse Responses Peripheral Bed Models |
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