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Philadelphia-chromosome-negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation |
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| Authors: | J F Kessler T M Grogan B R Greenberg |
| Abstract: | A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine and prednisone and the rapid downhill course. |
| Keywords: | leukemia myelogenous lymphoid transformation |