| 腹腔巨噬细胞对急性胰腺炎大鼠腹腔炎症反应的影响 |
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| 引用本文： | 范家乔,毕伟,陈海龙. 腹腔巨噬细胞对急性胰腺炎大鼠腹腔炎症反应的影响[J]. 军医进修学院学报, 2009, 30(3): 366-368 |
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| 作者姓名： | 范家乔 毕伟 陈海龙 |
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| 作者单位： | 大连医科大学附属一院,普外三科,大连,116021 |
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| 摘 要： | 目的：研究腹腔巨噬细胞（peritoneal macrophages,PMs）对实验性胰腺炎大鼠腹腔炎症反应的影响。方法：胰胆管逆行注射2%去氧胆酸钠制作出血坏死性胰腺炎大鼠模型,使用氯屈磷酸二钠脂质体（Liposome-CL2MBP）腹腔注射特异性清除腹腔巨噬细胞,采用纯雄性S-D大鼠24只,随机分为腹腔巨噬细胞保留/PMs（＋）组、腹腔巨噬细胞清除/PMs（-）组和假手术/SO组。造模后12h活杀大鼠取标本,做胰腺病理学检查,血清淀粉酶测定,腹水定量,检测腹水细胞因子和一氧化氮水平。结果：PMs（-）组和PMs（＋）组间在胰腺病理学评分、血清淀粉酶水平方面无显著差异,两组在腹水定量、腹水细胞因子和一氧化氮水平方面差异显著（P〈0.05）。结论：腹腔巨噬细胞对急性胰腺炎大鼠腹腔炎症反应有重要影响。
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| 关 键 词： | 胰腺炎 急性坏死性 细胞因子类 一氧化氮 脂质体 巨噬细胞,腹膜 |
Effect of peritoneal macrophages on peritonitis of rats with acute pancreatitis |
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| FAN Jia-qiao,BI Wei,CHEN Hai-long. Effect of peritoneal macrophages on peritonitis of rats with acute pancreatitis[J]. Academic Journal of Pla Postgraduate Medical School, 2009, 30(3): 366-368 |
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| Authors: | FAN Jia-qiao BI Wei CHEN Hai-long |
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| Affiliation: | Department of the Third General Surgery;First Affiliated Hospital of Dalian Medical University;Dalian 116021;China |
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| Abstract: | Objective:To study the effect of peritoneal macrophages(PM) on peritonitis of rats with experimental pancreatitis.Methods:A model of hemorrhagic necrotic pancreatitis was established by retrograde injection of 2% sodium deoxycholate into the common biliopancreatic duct of rats.Liposome-CL2MBP was injected into the peritoneum to exhaust PM of rats.Twenty-four male rats were randomly divided into PMs(+) group,PMs(-) group and sham operation group.The rats were killed 12h after the model was established to tak... |
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| Keywords: | pancreatitis acute necrotizing cytokines nitric oxide liposomes macrophages peritoneal |
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