| 联合化疗对急性白血病患儿脑脊液中三种激素水平的影响 |
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| 引用本文： | 朱长连,王小阳,贾莉婷,刘东峰.联合化疗对急性白血病患儿脑脊液中三种激素水平的影响[J].中国小儿血液与肿瘤杂志,1998(2). |
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| 作者姓名： | 朱长连 王小阳 贾莉婷 刘东峰 |
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| 作者单位： | 河南医科大学第三附属医院!450052 |
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| 摘 要： | 随着联合化疗的进展，小儿急性白血病长期存活人数增多，化疗的副作用特别是对儿童生长的影响也逐渐引起了人们的关注（1）。联合化疗对儿童生长发育的影响可能是多方面的，但对激素的影响如何未见详细报道，我们对此进行了初步研究。对象和方法一、对象急性白血病患儿21例，男16例，女5例，年龄2卞～13岁，中位数65岁。其中急性淋巴细胞白血病17例，急性非淋巴细胞白血病4例。联合化疗根据细胞类型决定联合化疗方案（急淋应用DOAP方案，急非淋用HOAP方案）。对照组15例，为非颅内疾病患儿，年龄2～12岁，中位数712岁，其中男性9例，女6…
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EFFECTS OF COMBINED CHEMOTHERAPY ON THREE HORMONES IN CEREBROSPINAL FLUID OF ACUTE LEUKEMIA CHILDREN |
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| Abstract: | For the purpose of evaluating the affection of combined chemotherapy on the level of hormone in cerebral spinal fluid, T4, TSH and GH in acute leukemia group before chemotherapy were no statistic difference compared with that of control group. After one course of chemotherapy, the GH level in cerebrospinal fluid was much lower than that of before chemotherapy and control (p〈O. 001 ). However, T4 and TSH were no marked changes in acute leukemia children before chemotherapy. It indicated that combined chemotherapy affects GH. It may be one of the reason of retardation in long live leukemia children. It suggested that giving GH to the retardation children of long live acute leukemia is suitable. |
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