一次性大剂量硝酸咪康唑治疗霉菌性阴道炎的疗效观察

目的比较一次性大剂量硝酸咪康唑阴道用药与7日常规硝酸咪康唑疗法治疗外阴阴道假丝酵母菌念珠菌病（vulvovaginal candidiasis，VVC）的疗效、安全性及耐受性。方法选择168例经临床确诊为霉菌性阴道炎的门诊患者，随机分为两组，每组84例，分别给予一次性1200mg硝酸咪康唑单剂量疗法（研究组），或硝酸咪康唑200mg连续7天疗法治疗（对照组），在治疗后第3天、第7天和第28天各随访1次，观察阴道霉菌、临床症状和体征，进行比较研究。结果两组在药物起始治疗后7天及28天在临床及阴道霉菌检查方面无统计学差异．但在药物起始治疗后3天研究组较对照组临床症状改善明显。结论一次性大剂量1200mg硝酸咪康唑阴道用药与7日传统硝酸咪康唑疗法在治疗VVC方面同样安全、有效。但一次性大剂量硝酸咪康唑起效更早．缓解症状更快。

The Clinical Observation of a Single-dose Miconazole Nitrate in Treating Vulvovaginal Candidiasis

OBJECTIVE To determine the efficiency, tolerance, treatment compliance and safety of a single-dose（l 200 mg）mieonazole nitrate compared with seven consecutive treatment of miconazoie nitrate （400 mg daily） in treating vulvovaginal candidiasis （VVC）, METHODS One hundred and sixty-eight outpatients with VVC were included and randomly placed in two groups of eighty-four patients each one. Each group was either given 1200 mg miconazole nitrate for one time or 200 mg daily for seven days. Before the pharmacological treatment, each patient was evaluated clinically and microhiologieally, as well as at the end of treatment （day 7） and one-month （day 28）after treatment. RESULTS A significantly greater proportion of patients in 1 200 mg group experienced complete symptom relief by clay 3, but no statistical differences werefound between either treatment group during clinical and microbiological evaluation when evaluated 7 or 28 days after pharmacological treatment. CONCLUSIONS The result reveals that a single-dose therapy with 1 200 mg miconazole nitrate is as safe andefficacious in curing VVC as seven consecutive treatment of miconazole nitrate intreating signs and symptoms of the infection as well as equally effective in the microbiological elimination of the causing agents of the VVC, but the time to complete relief was significantly faster in a single-dose of 1 200 mg miconazole nitrate.