喹诺酮类抗菌药物的临床不良反应

目的综述喹诺酮类抗菌药物所致临床不良反应的情况,为临床合理使用抗菌类药物提供警示,预防该类药物不良反应的发生。方法对国内外近期公开报道的喹诺酮类抗菌药物临床不良反应进行总结与分析。结果喹诺酮类药物的主要临床不良反应有消化系统反应、过敏反应、光敏反应、中枢神经系统反应、心血管系统反应、肝、肾功能损害、血液系统反应、软骨毒性和肌腱损伤以及影响血糖等。结论喹诺酮类抗菌药物引起的不良反应症状多,涉及系统广泛,有的后果严重,临床医生应严格掌握适应证,高度重视药品不良反应的监测,发现不良反应及时采取有效措施,提高用药的安全性。

Clinical Adverse Reactions of Quinolone Antibacterial Drugs

Objective By reviewing clinical adverse reactions of quinolone antibacterial drugs, to provide warning for the clinical rational use of antimicrobial drugs, and to prevent the adverse reactions happening of this kind of drug. Methods The related references about clinical adverse reactions of quinolone antibacterial drugs at home and abroad in recent years were collected, summarized and analyzed. Results The main clinical adverse reactions of quinolone drugs were the digestive system reaction, allergic reaction, photosensitized reaction, central nervous system reaction, cardiovascular system reaction, liver and kidney function damage, the blood system reaction, cartilage toxicity, tendon injuries and the influence on blood glucose, etc. Conclusion The symptomsf adverse reactions caused by the quinolone antibacterial drugs were numerous, involving many systems with some serious serious consequences in some cases, so clinical doctors should strictly master indications, reasonably choose medicine, attache great importance to adverse reactions monitoring, immediately take effective measures once the adverse reactions occur, so as to improve the safety of drugs.