基于功效和物质基础的雷公藤毒性研究进展

目的为进行功效和毒性导向下的化学成分分离、控制和功效与毒性成分的“量效关系”和“量毒关系”研究指供文献依据和研究思路。方法对文献古籍中对雷公藤毒性的记载及近十几年来国内外相关文献对雷公藤的报道趟行整理、分析与归纳。结果与结论只有在雷公藤功效表达和功效物质基础分离与控制的过程中，进行毒性的研究莉毒性物质基础的安全控制，才能提出切合雷公藤临床使用过程中预防药品不良反应的预警方案和早期诊疗措施，确保雷公藤临床用药安全。

Research Development on Toxicity of Tripterygium wilfordii Related to Efficacy and Chemical Material Basis

Objective To provide literature evidences and research ideas of efficacy and toxicity of the chemical composition of guided separation, control and efficacy, and the research on the ＂dose-effect relationship＂ and ＂dose- toxicity relationship＂ about the toxical components. Methods References in old days and in the last decades both at home and abroad about Tripterygium wilForddi were collated, analyzed and summarized. Results and Conclusion The research on Tripteryggium wilForclii about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction, the early diagnosis and treatment measures that can be referred to clinical usage. Tripterygium wil~orcfii will be ensured to use safely as a clinical drug.