190例他汀类降脂药品不良反应病例分析

目的探讨他汀类降脂药品导致不良反应发生的可能原因和影响因素,为血脂异常人群长期安全用药提供建议。方法对四川省自2004年1月至2012年6月期间,通过国家药品不良反应监测系统网络上报的190例他汀类降脂药品致不良反应病例报告进行统计分析。结果他汀类降脂药品的不良反应以皮疹、肌损害、胃肠道反应、肝功能损害为主;部份不良反应累及神经系统和血液系统;严重不良反应以肝损害最常见。结论应规范降脂用药的剂量和时限,避免超时与超剂量用药,加强院外患者的用药后复诊和随访,减少不良反应的发生。

Analysis of 190 Reports of Adverse Drug Reaction Induced by Statins

Objective To investigate the characteristics and influence factors of adverse drug reactions（ADR） induced by statins. Methods 190 reports of adverse drug reactions induced by statins, collected from Sichuan AD1K Monitoring Center via National ADR Monitoring System from Jan. 2004 to Jun. 2012 were analyzed. Results Skin lesions, muscle lesions, gastrointestinal system and liver function failure were the most common adverse reaction of statins, some nervous system and blood system abnormals followed. The serious adverse reactions frequently involved liver dysfunction. Conclusion Lipid-lowering drugs should be strictly regulated by dose and time-limit, to avoid any overtime or overdose medication. To emphasize the return consultation and follow-ups of out-patients may reduce the incidence of adverse reaction in statins.