直肠癌远端黏膜Cox-2及Bcl-2蛋白的表达及其临床意义

目的探讨直肠癌远端黏膜Cox-2及Bcl-2蛋白的表达情况，判断直肠癌手术的远端安全切除范围。方法应用免疫组织化学S—P法检测54例直肠癌远端2cm及3cm黏膜组织、肿瘤组织和20例手术切除的直肠正常黏膜组织中Cox-2和Bcl-2蛋白的表达情况。结果直肠癌远端2cm、3cm黏膜组织与肿瘤组织中Cox-2和Bcl-2蛋白的表达差异有统计学意义（P〈0．05），与直肠正常黏膜组织中的表达差异则无统计学意义（P〉0．05）。在不同的肿瘤临床病理参数中，直肠癌远端2cm、3cm黏膜组织中Cox-2和Bcl-2蛋白的表达也无明显差异（均P〉0．05）结论直肠癌远端2cm、3cm黏膜组织中Cox-2与Bcl-2蛋白的表达与正常组织无差异，提示直肠癌远端切除2cm已经足够。

Expressions and significance of Cox-2 and Bcl-2 protein in distal mucosa adjacent to rectal carcinoma

Objective To detect the expression of Cox-2 protein and Bcl-2 protein in distal mucosa adjacent to rectal carcinoma, and judge the distal resection margin of rectal cancer. Methods Immunohistochemical method was used to investigate the expressions of Bcl-2 and Cox-2 protein in the 54 specimens of rectal carcinoma mass, distal mucosa 2cm and 3era away from rectal turmor, and 20 cases of normal rectal mucosa. Results The expressions of Cox-2 and Bcl-2 protein were detected in carcinoma mass and distal mucosa. Significant contrast was observed for carcinoma mass and distal mucosa （ P 〈 0.05 ） , but there were no significant contrast between distal rnucosa and normal rectal mucosa（ P 〉 0.05 ）. Conclusions It is sufficient to reseet distal mucosa 2 cm away from rectal turmor.