Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells |
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| Authors: | Shaw Robert K Smollett Katherine Cleary Jennifer Garmendia Junkal Straatman-Iwanowska Ania Frankel Gad Knutton Stuart |
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| Affiliation: | Institute of Child Health, University of Birmingham, Whittall St., Birmingham B4 6NH, United Kingdom. |
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| Abstract: | Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules. |
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