| 清道夫受体BI与动脉粥样硬化 |
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| 引用本文： | 杜芬,喻红.清道夫受体BI与动脉粥样硬化[J].中国动脉硬化杂志,2018,26(11):1177-1183. |
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| 作者姓名： | 杜芬 喻红 |
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| 作者单位： | 武汉大学基础医学院 湖北省发育源性疾病重点实验室,湖北省武汉市 430071,武汉大学基础医学院 湖北省发育源性疾病重点实验室,湖北省武汉市 430071 |
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| 基金项目： | 国家自然科学基金面上项目(81670423、81670412、81270364) |
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| 摘 要： | 清道夫受体B族I型(SR-BI)是细胞膜上首个被定义为高密度脂蛋白(HDL)受体的糖蛋白,其介导细胞选择性摄取高密度脂蛋白胆固醇(HDLC),影响细胞胆固醇平衡、炎症表型。肝脏SR-BI在胆固醇逆向转运中扮演重要角色,而与HDL的代谢及其抗动脉粥样硬化(As)作用密切相关,并且已发现人类存在SR-BI基因多态性。本文重点从SR-BI结构、功能、调节及其对As的作用进行综述。
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| 关 键 词： | 清道夫受体BI 高密度脂蛋白 胆固醇代谢 动脉粥样硬化 |
| 收稿时间： | 2018/6/15 0:00:00 |
| 修稿时间： | 2018/7/13 0:00:00 |
Scavenger receptor BI and atherosclerosis |
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| DU Fen and YU Hong.Scavenger receptor BI and atherosclerosis[J].Chinese Journal of Arteriosclerosis,2018,26(11):1177-1183. |
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| Authors: | DU Fen and YU Hong |
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| Institution: | School of Basic Medical Sciences, Wuhan University & Hubei Key Laboratory of Developmental Diseases, Wuhan, Hubei 430071, China and School of Basic Medical Sciences, Wuhan University & Hubei Key Laboratory of Developmental Diseases, Wuhan, Hubei 430071, China |
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| Abstract: | Scavenger receptor type B class I (SR-BI) is the first glycoprotein defined as a high density lipoprotein (HDL) receptor on the cell membrane, which mediates the selective uptake of high density lipoprotein cholesterol (HDL) by cells, affecting cell cholesterol balance and inflammatory status. Liver SR-BI plays an important role in reverse cholesterol transport, and is closely related to HDL metabolism and its role in anti-atherogenesis. It has been found that humans have SR-BI gene polymorphisms. This review focuses on SR-BI structure, function, regulation and its role on atherosclerosis. |
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| Keywords: | scavenger receptor BI high density lipoprotein cholesterol metabolism atherosclerosis |
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