冠状病毒的分子生物学研究进展

冠状病毒是所有RNA病毒中基因组最大的病毒，具有胃肠道、呼吸道或神经系统嗜性，常引起人普通感冒或动物胃肠道、呼吸系统疾病，而SARS-CoV则引起人的严重急性呼吸道综合征。研究冠状病毒分子生物学特征对阐明其病毒粒子的发生、感染和致病机制有重要意义。本文就冠状病毒的分子生物学特征包括冠状病毒基因组特征，编码蛋白的结构及功能等方面的研究进展作一综述。

Progress of molecular biological study on coronavirus

Coronavirus,being the biggest RNA virus,has gastrointestinal tract,respiratory tract or nervous system tropism.In humans,it can cause common cold,in animal and fowl,gastroenteritis or disease of respiratory system can be evoked.Since SARS-CoV,caused severe acute respiratory syndrome(SARS) in human beings,so study on the molecular biological characterization of coronavirus was essential for the elucidation of generation of virus particle,infection and pathopoiesis mechanism.This article reviewed the molecular biological characterization of coronavirus including the characterization of genome,structure and function of protein of the virus et al.