老年人EB病毒阳性弥漫大B细胞淋巴瘤的研究进展 |
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引用本文: | 叶云霞,张文燕. 老年人EB病毒阳性弥漫大B细胞淋巴瘤的研究进展[J]. 白血病.淋巴瘤, 2015, 0(11): 700-704. DOI: 10.3760/cma.j.issn.1009-9921.2015.11.021 |
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作者姓名: | 叶云霞 张文燕 |
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作者单位: | 四川大学华西医院病理科, 成都,610041 |
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摘 要: | Epstein-Barr病毒(EBV)是与多种人类肿瘤的发生密切相关的DNA病毒.在2008版WHO关于淋巴造血组织肿瘤分类中,老年人EBV阳性弥漫大B细胞淋巴瘤(DLBCL)被作为非特指DLBCL的一个新的变异型,该变异型具有与其他DLBCL亚型不同的形态学和生物学特征.现对老年人EBV阳性DLBCL的病因及发病机制、临床病理特点、免疫表型、遗传学改变、诊断和鉴别诊断以及预后进行综述.
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关 键 词: | 淋巴瘤,大B细胞,弥漫型 老年人 EB病毒 |
Research progress of Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly |
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Abstract: | Epstein-Barr virus (EBV) is a DNA virus linked to a variety of human malignant tumors.In the 2008 WHO classification of lymphatic hematopoietic tissue tumor,EBV positive DLBCL of the elderly had been a new variant.The characteristic of this variant is different from other DLBCL subtypes.This paper summarized the etiology,pathogenesis,clinicopathologic features,immunophenotype,genetic changes,differential diagnosis and prognosis of EBV positive DLBCL of the elderly. |
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Keywords: | Lymphoma,large B-cell,diffuse Elderly Epstein-Barr virus |
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