| Abstract: | Changes in the surface and intracellular structure of erythrocytes in conjunction with the general morphological picture of the blood were studied experimentally. In hypoxic hypoxia changes take place in mature erythrocytes and in bone-marrow tissue erythroblasts. In the early stages of hypoxia (first to fifth days) the number of erythrocytes, their respiratory surface, and their hemoglobin content all increase. These changes are adaptive. In the later stages of hypoxia (10th–15th days) there is no increase in the number of erythrocytes, the number of reticulocytes falls, and erythroblasts disappear, i.e., the erythroblasts capacity of the bone marrow is exhausted and signs of its decompensation appear. The increase in the number of erythrocytes and the hemoglobin concentration in the blood are the result of stimulation of the function of the erythroid series of the bone marrow, as is shown by an increase in the number of reticulocytes in the peripheral blood and the appearance of erythroblasts.Laboratory of Pathological Anatomy and Postmortem Examination, A. N. Bakulev Institute of Cardiovascular Surgery, Academy of Medical Sciences of the USSR, Moscow. Department of Cytology, A. N. Natishvili Institute of Experimental Morphology, Academy of Sciences of the Georgian SSR, Tbilisi. (Presented by Academician of the Academy of Medical Sciences of the USSR M. N. Solov'ev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 502–506, October, 1978. |
