| 吗啡耐受过程中脊髓胶质细胞作用机制研究进展 |
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| 引用本文： | 肖建斌,项红兵,招伟贤. 吗啡耐受过程中脊髓胶质细胞作用机制研究进展[J]. 国际麻醉学与复苏杂志, 2007, 28(4): 327-330 |
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| 作者姓名： | 肖建斌 项红兵 招伟贤 |
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| 作者单位： | 广州中医药大学第二附属医院麻醉科,510120;广州中医药大学第二附属医院麻醉科,510120;广州中医药大学第二附属医院麻醉科,510120 |
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| 摘 要： | 吗啡镇痛耐受是指重复使用吗啡引起抗伤害性效应的时间依赖性抑制。最近，许多报告显示重复使用吗啡后脊髓背角胶质细胞（星形胶质细胞和小胶质细胞）明显增加，其特征是胶质纤维酸性蛋白（GFAP）阳性细胞和OX-42阳性细胞数量增加，以及形态学发生变化。此文综述了吗啡镇痛耐受过程中脊髓胶质细胞作用机制的研究进展。
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| 关 键 词： | 星形胶质细胞 小胶质细胞 吗啡镇痛耐受 |
Advances of the mechanisms underlying the relationship between spinal gliacytes and the development of morphine-induced analgesia tolerance |
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| XIAO Jian-bin,XIANG Hong-bing,ZHAO Wei-xian. Advances of the mechanisms underlying the relationship between spinal gliacytes and the development of morphine-induced analgesia tolerance[J]. international journal of anesthesiology and resuscitation, 2007, 28(4): 327-330 |
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| Authors: | XIAO Jian-bin XIANG Hong-bing ZHAO Wei-xian |
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| Affiliation: | Department of Anesthesiology, the Second Affiliated Hos- pital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China |
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| Abstract: | |
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| Keywords: | astrocytes microglia morphine - induced analgesia tolerance |
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