A study of the myocardial protective effect of rapid cooling based on intracellular Ca, intracellular pH, and HSP70. |
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| Authors: | Koichi Inoue Susumu Ando Fan Gyuan Toshihiro Takaba |
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| Institution: | First Department of Surgery, Showa University School of Medicine, Tokyo, Japan. |
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| Abstract: | Objective: It has been reported that rapid cooling of the heart during normothermic coronary circulation at reperfusion after ischemia promotes early recovery of cardiac function due to the positive inotropic effects on the myocardium produced by cooling. The aim of the present study was to investigate the myocardial protective effect of rapid cooling by measuring heat shock protein (HSP) levels and examining the relationship between cardiac function, intracellular Ca concentration, and intracellular pH after rapid cooling. Methods: Isolated perfused rat hearts were subjected to ischemia for 60 minutes at a myocardial temperature of 37 degrees C. One group of hearts (group R) was subjected to 3 minutes of rapid cooling (
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