前列腺癌患者外周血Matriptase和VEGF检测及其临床意义

目的 联合检测前列腺癌患者外周血中Matriptase和血管内皮生长因子(vascular endothelial growth factor，VEGF)的表达、与前列腺癌临床参数的关系，探讨其临床意义。方法 采用酶联免疫吸附ELISA法检测47例前列腺癌（其中20例远处转移）、45例良性前列腺疾病（20例前列腺炎、2...

Serum levels and significance of Matriptase and VEGF in patients with prostate cancer

Objectives To investigate the serum levels of Matriptase and vascular endothelial growth factor (VEGF) in patients with prostate diseases,and their relationship with the clinicopathological parameters,and evaluate its significance for diagnosing prostate cancer. Methods The serum levels of specimens of 122 cases ,27 localized prostate cancer,20 metastatic prostate cancer,20 chronic prostatitis (CP) ,25 benign prostatic hyperplasia( BPH), 10high - grade intraepithelial neoplasias( PIN), and 20 NP were selected, were detected by ELISA. Results Serum levels of Matriptase and VEGF were significantly higher in patients with prostate cancer than those in BPH, CP, PIN,and NP( p ＜0.01 ),There no significant difference in BPH, PIN, CP, and NP groups; The positive correlation was noted between Matriptase and VEGF expression, and both of them were significantly related to the tumor pathologic grades and tumor clinical stage( p ＜0.05 ). Serum concentrations of Matriptase and VEGF in patients with metastatic prostate cancer was significantly higher than that in localized prostate cancer( p ＜ 0. 01 ). Conclusions Serum level of Matriptase and VEGF are closely related to the histopathological grading, the tumor differentiation and prognosis of Pca;The combined detection of Matriptase and VEGF could be used as parameters for assessing the biological behavior and prognosis of Pca.