| 生存素及其在肿瘤研究中的意义 |
| |
| 引用本文： | 芮萌,段蕴铀. 生存素及其在肿瘤研究中的意义[J]. 国际呼吸杂志, 2011, 31(16): 1243-1247. DOI: 10.3760/cma.j.issn.1673-436X.2011.016.011 |
| |
| 作者姓名： | 芮萌 段蕴铀 |
| |
| 作者单位： | 海军总医院干部病房呼吸科,北京,100048 |
| |
| 摘 要： | 生存素(survivin)是凋亡抑制蛋白家族成员，同时参与细胞周期和凋亡的调节，在决定细胞生存中起重要作用。人类基因组中survivin是肿瘤最为特异性的基因之一，与临床不良预后密切相关，并因在肿瘤靶向治疗中的优势而倍受关注。本文从分子生物学、功能、在肿瘤诊治中的意义等方面对survivin作一简述。
|
| 关 键 词： | 生存素 肿瘤 预后 治疗 RNA干扰 |
Survivin and its significance in tumor research |
| |
| RUI Meng,DUAN Yun-you. Survivin and its significance in tumor research[J]. International Journal of Respiration, 2011, 31(16): 1243-1247. DOI: 10.3760/cma.j.issn.1673-436X.2011.016.011 |
| |
| Authors: | RUI Meng DUAN Yun-you |
| |
| Abstract: | Survivin, a member of the inhibitor of apoptosis protein family that takes part in cell division and apoptosis, and plays a pivotal role in determining cell survival. It is one of the most tumorspecific genes in the human genome and is associated with a poor clinical outcome. Survivin has attracted growing attention as a promising target for tumor therapy. This article reviews the molecular biology and function of survivin, and its significance in tumor diagnosis and treatment. |
| |
| Keywords: | Survivin Tumor Prognosis Treatment RNA interference |
| 本文献已被 万方数据 等数据库收录！ |
|
