1-磷酸鞘氨醇与肺缺血/再灌注损伤

背景1-磷酸鞘氨醇(sphingosine-1 -phosphate，S1P)是鞘脂的代谢产物，不仅与细胞表面特定受体(S1PR1-5)结合产生多种生物学效应，还作为细胞内第二信使发挥作用。S1P在细胞增殖、移动、凋亡及心血管系统、免疫系统等方面都有重要的调节作用，因而参与到生物体内许多生理和病理过程。目的现就近年来的...

The effect of sphingosine-1-phosphate on pulmonary ischemia/reperfusion injury

Background Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite. S1P can not only regulate various biological effects by binding the specific receptor (S1P G protein-coupled receptors, S1PR1-5) on cell surface, but also act as an intracellular second messenger. S1P has a pivotal role in cell proliferation, migration, apoptosis and cardiovascular system and immune system. Thus, it involves in some physiological and pathological progress. Objective This article intends to provide a review about the function of S1P in pulmonary ischemia/reperfusion injury (PI/RI), based on published data recently. Content Recent studies suggest that, through regulating inflammation, anti-apoptosis and maintaining endothelial cell barrier, S1P can affect the occurrence and development of PIRI. Trend With the further research on S1P, it offers several novel therapeutic strategies for the treatment of PI/RI.