Nrf2-Keap1系统防御紫外线致皮肤光损伤的研究进展

紫外线照射是致皮肤光损伤的重要因素，与其可诱导产生过量的活性氧族有关。核转录相关因子是调节抗氧化应激反应的重要转录因子，Kelch样ECH联合蛋白1是其特异性受体，在紫外线照射等氧化应激情况下核转录相关因子被激活，并与Kelch样ECH联合蛋白1解离进入胞核，启动抗氧化反应元件调控的Ⅱ相酶及抗氧化酶基因的表达，防御紫外线照射所致皮肤光损伤。多种核转录相关因子激活剂对紫外线照射所致皮肤光损伤有潜在的防御作用。

Nrf2-Keap1 system protects the skin from ultraviolet damage: an update

Ultraviolet irradiation is an important environmental factor causing skin photodamage, which is associated with the induction of reactive oxygen species (ROS) generation. Nuclear factor E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant responses, and kelch-like ECH-associated protein 1 (Keap1) is its specific receptor. After activated by ultraviolet-induced oxidative stress or other factors, Nrf2 detaches from Keap1 and enters into the cell nucleus followed by the triggering of expression of antioxidase genes and antioxidant response element-regulated phase 2 enzyme genes, which in turn protect the skin from ultraviolet damage. Many agonists of Nrf2 have a potential protective effect against ultraviolet-induced injury to skin.