帕瑞昔布结合切口局麻用于腹腔镜胆囊切除术后的镇痛效果

目的观察帕瑞昔布（特耐）结合切口局麻用于腹腔镜胆囊切除术后的镇痛效果。 方法选择全麻下行腹腔镜胆囊切除术患者50例，按随机数字表随机双盲分为特耐组和对照组，每组25例。术前10 min实验组静注特耐40 mg，对照组静注同等容量的生理盐水。所有病例均于切皮前在脐部切口处以0.375％布比卡因8ml全层浸润。观察时间点...

Postoperative analgesic effect of parecoxib following laparoscopic cholecystectomy combined with incision infiltration by local anesthetics

Objective To investigate the postoperative analgesic effect of parecoxib following laparoscopic cholecystectomy when local anesthetics was infiltrated at incision site. Methods Fifty patients undergoing laparoscopic cholecystectomy were randomized into two groups in a double-blind manner: patients in the experimental group received intravenous parecoxib 40 mg 10 min before operation, and patients in the control group received intravenous normal saline in same volume. All the patients received incision infiltration with 0.375％ bupivacaine 8ml at navel before the operations. The observation time points included T1 (departure from the PACU), T2 (5 h after the operation) and T3 (the morning of postoprative day 1 ). VAS values, additional requirement of opioids analgesia, the rate of satisfactory with analgesia quality and sleep quality was compared between two groups. Results The VAS values in the experimental group were significantly lower than that in the control group at time point T1 and T2 (T1 : 1.6±±0.5 vs 3.6±0.7, T2: 1.8±0.6 vs 3.5±0.9, P＜0.05), while VAS was lower in the experimental group at T3, but the difference had no Statistical significance. The rate of satisfactory with analgesia and sleep quality in the experimental group was significantly higher than that in the control group. Conclusion Paricoxib combined with local anesthetics infiltration can significantly relieve the postoperative pain in the patients receiving laparoscopic cholecystectomy.